Spain obtains complete genome sequence of monkeypox virus


This large-scale sequencing work confirms that the West African variety is the cause of this less severe outbreak.

monkey pox
Monkeypox virus as seen under a microscope.ISC III
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researchers of Carlos III Institute of Health (ISCIII)depend on Ministry of Healthhas acquired the first complete sequence draft of the monkeypox virus (monkeypox), obtained from genomic analysis of 23 patients’ samples.

This large-scale sequencing work confirms that it is a diversity of West Africa cause of this outbreak. In addition, sequencing has reached 100% coverage of 190,000 base pairs of the genome of this virus, which opens up the possibility of more advanced phylogenetic studies that will allow additional information on its behavior and a better understanding of its origin, circulation . and spread.

This is one of the most complete sequences ever obtained. done through sequencing Arbovirus Laboratory The ISCIII’s, in conjunction with the ISCIII’s Genomics and Bioinformatics Units, have relied on references published in recent times by other countries (Blagica, Germany, Portugal You America), and is based on a new-generation genomic technology mapped against the reference genome, adding a complementary analysis of samples using a technique called de novo assembly.

samples from the same outbreak

The raw sequences ended last Monday night and have been computer analyzed over the past 36 hours. The results indicate that the sequenced samples appear to be related to similar outbreaks found in other European countries, as the genomes obtained hardly differ from those previously sequenced in other countries.

Specifically, the analysis performed in ISCIII concluded that there are fewer than 5 SNPs (genetic sequences called single nucleotide changes) of difference with respect to the sequence carried in the sequence. Germany, sequencing confirms that the virus monkey pox The outbreak in Spain is from the West African clade, which is the least virulent among those known and has so far been identified in most countries outside Africa involved in the outbreak.

Clades are the phylogenetic groups that define the biological evolution of an organism, explain how it functions and behaves, and the genetic differences observed in circulating viruses. After obtaining the complete sequence of the virus, several teams of ISCIII researchers are carrying out phylogenetic analysis to trace the relationship between the Spanish samples and samples from other countries.

The information obtained will be compared with information already known and deposited in international databases to assess the degree of identification and, where appropriate, the location of differences that exist between the Spanish sequence and other international data. All this will allow the study of the ability to trace the outbreak, as well as potentially identify its origin.

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