They do the liver transplant for the first time after spending three days outside the donor’s body.


The technology used, a perfusion machine, makes it possible to pre-condition the organs available for transplantation by conditioning them, and to schedule interventions.

Surgeon, Prof.  Pierre-Alain Clavien, and the patient when it
Surgeon, Prof. Pierre-Alain Clavien, and the patient when discharged from the hospital after successful transplantation.def

A new perfusion machine has allowed the liver to be transplanted after spending three days outside the body. was part rejected for transplant For not meeting the optimal conditions (he was affected by an infection and a possible tumor).

with this proof of concept A medical-surgical team from the University Hospital of Zurich (USZ) in Switzerland demonstrates that they have improved the normothermic perfusion system Besides To be able to successfully graft the organ. transplanted patient lives healthy one year after the procedureAccording to the authors of this advance published in the journal nature biotechnology,

The person responsible for this transplant, Pierre-Alain ClavienThe director of the USZ’s Department of Surgery and Transplantation, El Mundo, summarized his progress as follows: “This machine is thatThe only one that allows long-term protection (for several days) outside the body. machine mimics all major body functions such as pulsating arterioles and continuous venous flow; control of glucose, energy and fat; There is physiological oxygen and a dialysis system that continuously removes all waste products.

The study authors recall that “current methods of organ preservation provide a narrow window (usually less than 12 hours) to evaluate, transport and implant grafts for human transplantation”.

Once transplanted, the liver “exhibited normal function, requiring minimal repopulation injury and minimal immunosuppressive regimens,” he says. patient, for his part, Suffering from several serious liver ailmentsincluding advanced cirrhosis and severe portal hypertension, and after transplant, “he rapidly returned to a normal quality of life with no signs of liver damage, such as rejection or injury to the bile ducts, at a one-year follow-up. according .”

This pioneering corruption case “opens new horizons in clinical research and promises” Extend the time window to 10 days To assess the viability of donor organs, as well as to convert an urgent and highly demanding surgery into an elective procedure,” declare the researchers. Specifically, Klavian explains that this window can last up to 12 days. Although he clarifies that this is not a confirmed fact.

For surgeons, optimization of organ perfusion techniques will allow, among other advances, to “evaluate and treat marginal or rejected grafts to perform safe transplants”, as well as Eliminate harmful fats and infections before transplanting the liver, and turning “A” emergency operation which is often done at night in a prescribed process,

In addition, Klavian recalls that these machines could work in “regeneration”. from site Thief self transplant without the need for immunosuppression” and contribute to modulating immunosuppression, thus reducing or eliminating its need. Finally, it also lists the possible Application in cancer treatment (by removing the tumor or giving chemotherapy) ex vivo) and in drug pharmacokinetic research.

Following the success of this case, the researchers caution that more research is needed with more patients and longer observation periods. However, they emphasize that the results of the technology they developed could contribute to not only increasing the number of organs potentially accessible for donation, but also to treating available organs with drugs prior to transplantation. can also improve the probability of

Swiss surgeon Pierre-Alain Clavien, trained in transplantation techniques at the universities of Toronto (Canada) and Duke (United States), is one of the promoters of this criterion system, with which he demonstrated functionally only a few years earlier. The injured human liver can be maintained for up to 10 days. That discovery was also published in 2020 nature biotechnology,

in an interview liver oncologyKlavian then spoke of the prospects of transferring this new device to the clinic, saying that they would first need to “transplant it into humans and ensure the long-term function of these livers. Once obtained, many of the livers that are present at are not suitable for use, they can be placed on this machine.On top of that, also the so-called liver high riskthey will be able to To bet Benefit from the repair process on and off the machine.

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